An Intracellular High Throughput Screening Platform to Derive Selective & Functional Transcription Factor Antagonists

Time: 11:30 am
day: Day One


• Protein-protein interactions, in particular Transcription Factors, are compelling drug targets yet often intractable to small molecule approaches
• In targeting such PPIs, peptides occupy an attractive middle ground between small molecules much larger biologics
• Utilize intracellular peptide library screening approaches to identify selective peptide-based inhibitors that are capable of functional target antagonism that is required within a complex cellular environment